CD34

CD34 is a transmembrane glycoprotein constitutively expressed on endothelial cells and on hematopoietic stem cells. This highly O-glycosylated molecule, containing serine and threonine-rich mucin like domains, binds to L-selectin, but its functional capacity in non-lymphatic venules is uncertain. Studies have suggested that CD34 is important in tethering lymphocytes.

Mice deficient in CD34 exhibited no detectable abnormalities in postsurgical leukocyte rolling in cremaster venules. Antibodies blocking L-selectin function reduced rolling in CD34 deficient mice suggesting that CD34 lacks major significance as a ligand for L-selectin. The endothelial ligands for L-selectin are currently unknown.

View various information about this molecule at the National Center for Biotechnology Information.

 

Search similar protein and nucleotide sequences between various species using BLAST (Basic Local Alignment Search Tool)
  • Copy the desired sequence from the GenBank Database and paste it into the text box on the BLAST page.
  • Search results will provide a list of homologous molecules and show a statistical relationship between high-scoring segment pairs.
  • For more information on the results, consult the BLAST Help Manual.

 

Read the following categorized abstracts or link to Medline to conduct your own query.

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