Chemokines

Table 1: CHARACTERISTICS OF CHEMOKINES
Glossary of Abbreviations

NC-IUPHAR Name	Human Common Names	Mouse Common Names	Gene Location	Leukocyte Receptors Bound	Chemokine Type	Expression & Function	Molecule Information
CXCL1	GROα, MGSA	MIP-2, KC*	4q12-q13	CXCR2	ELR+	Inducible, Inflammatory	Mus musculus Homo sapiens
CXCL2	GROβ, MIP-2α	KC*	4q12-q13	CXCR2	ELR+	Inducible, Inflammatory	Mus musculus Homo sapiens
CXCL3	GROγ, MIP-2β	KC*	4q12-q13	CXCR2	ELR+	Inducible, Inflammatory
CXCL4	PL4	PL4	4q12-q13		ELR-		Mus musculus Homo sapiens
CXCL5	ENA-78	LIX*	4q12-q13	CXCR2	ELR+	Inducible, Inflammatory	Mus musculus Homo sapiens
CXCL6	GCP-2	CKα-3	4q12-q13	CXCR1,2	ELR+	Inducible, Inflammatory	Homo sapiens
CXCL7	NAP-2		4q12-q13	CXCR2	ELR+	Inducible, Inflammatory	Mus musculus Homo sapiens
CXCL8	IL-8		4q12-q13	CXCR1,2	ELR+	Inducible, Inflammatory	Homo sapiens
CXCL9	Mig	Mig	4q21	CXCR3	ELR-	Inducible, Inflammatory	Mus musculus Homo sapiens
CXCL10	IP-10	IP-10, CRG-2	4q21	CXCR3	ELR-	Inducible, Inflammatory	Mus musculus Homo sapiens
CXCL11	I-TAC, IP9		4q21	CXCR3	ELR-	Inducible, Inflammatory	Mus musculus Homo sapiens
CXCL12	SDF-1	SDF-1	10q11	CXCR4	ELR-	Constitutive, Homeostasis	Mus musculus Homo sapiens
CXCL13	BLC, BCA-1	BLC, BCA-1	4q21	CXCR5	ELR-	Constitutive, Homeostasis	Mus musculus Homo sapiens
CXCL14	BRAK,bolekine				ELR-		Mus musculus Homo sapiens
CXCL15		lungkine			ELR-		Mus musculus Homo sapiens
CXCL16	CXCL16	CXCL16		CXCR6	ELR-, TMD	Constitutive, Homeostasis	Mus musculus Homo sapiens
CCL1	I-309	TCA-3, P500	17q11	CCR8	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL2	MCP-1, MCAF	JE*	17q11	CCR2	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL3	MIP-1α, LD78α	MIP-1α	17q11	CCR1,5	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL4	MIP-1β	MIP-1β	17q11	CCR5,8	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL5	RANTES	RANTES	17q11	CCR1,3,5	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL6		C10, MRP-1	17q11		4 cysteines		Mus musculus Homo sapiens
CCL7	MCP-3	MARC*	17q11	CCR1,2,3	6 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL8	MCP-2	MCP-2*	17q11	CCR3	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL9		MRP-2, MIP-1γ	17q11		6 cysteines		Mus musculus Homo sapiens
CCL10		CCF18	17q11		4 cysteines
CCL11	eotaxin	eotaxin	17q11	CCR3	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL12		MCP-5	17q11	CCR2	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL13	MCP-4		17q11	CCR2,3	4 cysteines	Inducible, Inflammatory	Homo sapiens
CCL14	HCC-1, CKβ1, MCIF		17q11	CCR1	4 cysteines		Homo sapiens
CCL15	HCC-2, Lkn-1,MIP-5		17q11	CCR1,3	6 cysteines		Homo sapiens
CCL16	HCC-4, LEC, Mtn-1	LCC-1	17q11	CCR1	4 cysteines		Homo sapiens
CCL17	TARC	TARC	16q13	CCR4	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL18	DC-CK1, PARC		17q11		4 cysteines	Constitutive, Homeostasis	Homo sapiens
CCL19	MIP-3β, ELC, ckβ11	MIP-3β, ELC	9p13	CCR7	4 cysteines	Constitutive, Homeostasis	Mus musculus Homo sapiens
CCL20	MIP-3α, LARC	MIP-3α, LARC	2q33-q37	CCR6	4 cysteines	Constitutive, Homeostasis	Mus musculus Homo sapiens
CCL21	6Ckine, SLC, ckβ9	SLC, TCA-4	9p13	CCR7	6 cysteines	Constitutive, Homeostasis	Homo sapiens
CCL22	MDC, STCP1	abcd-1, dc/β-ck	16q13	CCR4	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL23	MPIF-1, ckβ8-1		17q11	CCR1	6 cysteines		Homo sapiens
CCL24	MPIF-2, eotaxin-2		7q11	CCR3	4 cysteines	Inducible, Inflammatory	Mus musculus Homo sapiens
CCL25	TECK, ckβ15	TECK, ckβ15	19p13	CCR9	4 cysteines	Constitutive, Homeostasis	Mus musculus Homo sapiens
CCL26	eotaxin-3, MIP-4α		7q11	CCR3	4 cysteines	Inducible, Inflammatory	Homo sapiens
CCL27	CTACK, ILC,ESkine	ALP, skinkine	9p13	CCR10	4 cysteines	Constitutive, Homeostasis	Mus musculus Homo sapiens
CX₃CL1	fractalkine	neurotactin	16q13	CX₃CR1	TMD⁺	both	Mus musculus Homo sapiens
XCL1	lymphotactin, ATAC	lymphotactin	1q23	XCR1	2 cysteines		Mus musculus Homo sapiens
XCL2	SCM-1β		1q23	XCR1	2 cysteines		Homo sapiens

* Mouse ligand has not been definitively linked to human ligand, but much similarity exists.
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Click to view the dendrogram for chemokines.

Table 2: CHARACTERISTICS OF CHEMOKINE RECEPTORS
Glossary of Abbreviations

Receptor	Gene Location	High Affinity Ligands	Functional Expression on Immune Cells	Molecule Information
CXCR1	2q34-q35	CXCL2,3,5,6,7,8	PMN, mast cells, monocytes, macrophages	homo sapiens
CXCR2	2q34-q35	CXCL1,2,3,5,6,7,8	PMN, mast cells, monocytes, macrophages	Mus musculus homo sapiens
CXCR3	Xq13	CXCL9,10,11	T-cells (Th1>Th2), B-cells, NK	Mus musculus homo sapiens
CXCR4	2pter-qter	CXCL12	most progenitor cells, T-cells, B-cells, PMN, monocytes, macrophages, DC	Mus musculus homo sapiens
CXCR5	11	CXCL13	B-cells, memory T-cells	Mus musculus homo sapiens
CXCR6		CXC16	memory T-cells	Mus musculus homo sapiens
CCR1	3p21	CCL3,5,7,14,15,16,23	memory T-cells, monocyte	Mus musculus homo sapiens
CCR2	3p21	CCL2,7,12,13	monocytes, DC, NK, T-cells, basophils, PMN	Mus musculus homo sapiens
CCR3	3p21	CCL5,7,8,13,15,24,26	eosinophils, basophils, mast cells, T-cells (Th2>Th1)	Mus musculus homo sapiens
CCR4	3p22	CCL17,22	T-cells (Th2>Th1)	Mus musculus homo sapiens
CCR5	3p21	CCL3,4,5	progenitors, Th1-cells, monocytes, macrophages, DC	Mus musculus homo sapiens
CCR6	6q27	CCL20	memory T-cells, DC	Mus musculus homo sapiens
CCR7	17q12-q21	CCL19,21	T-cells, B-cells, DC	Mus musculus homo sapiens
CCR8	3p22-p23	CCL1,4	Th2 Cells	Mus musculus homo sapiens
CCR9	3p21-p22	CCL25	α4b7+ T-cells, DC, macrophages	Mus musculus homo sapiens
CCR10	17q21	CCL27	CLA+ T-cells	Mus musculus homo sapiens
CCR11	3p22	CCL2,8,13
CX₃CR1	3p21	CX₃CL1	PMN, monocytes, NK, T-cells	Mus musculus homo sapiens
XCR1	3p21	XCL1,XCL2	T-cells	Mus musculus homo sapiens

Click to view the dendrogram on chemokine receptors.

Reference: T. S. Olson and K. Ley. Chemokines and chemokine receptors in leukocyte trafficking. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 283 (1):R7-R28, 2002

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