Mac-1, also called CD11b/CD18, is stored in specific granules which are shuttled to the granulocyte surface. It exists as a chemoattractant activation-dependent molecule that undergoes a conformational change upon stimulation. Expression of new epitopes on Mac-1 can be detected after activationby specific reporter monoclonal antibodies. Until stimulation occurs, Mac-1 remains in a resting, non-adhesive state. Activation of Mac-1 may play a role during neutrophil recruitment to the inflamed site. Interestingly, Mac-1 knockout mice have no inflammatory defect.

View various information about this molecule at the National Center for Biotechnology Information.


Search similar protein and nucleotide sequences between various species using BLAST (Basic Local Alignment Search Tool)
  • Copy the desired sequence from the GenBank Database and paste it into the text box on the BLAST page.
  • Search results will provide a list of homologous molecules and show a statistical relationship between high-scoring segment pairs.
  • For more information on the results, consult the BLAST Help Manual.


Read the following categorized abstracts or link to Medline to conduct your own query.

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