Mac-1 |
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Mac-1, also called CD11b/CD18, is stored in specific granules which are shuttled to the granulocyte surface. It exists as a chemoattractant activation-dependent molecule that undergoes a conformational change upon stimulation. Expression of new epitopes on Mac-1 can be detected after activationby specific reporter monoclonal antibodies. Until stimulation occurs, Mac-1 remains in a resting, non-adhesive state. Activation of Mac-1 may play a role during neutrophil recruitment to the inflamed site. Interestingly, Mac-1 knockout mice have no inflammatory defect.
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