VCAM-1

VCAM-1 (vascular cell adhesion molecule-1), or CD106, contains six or seven immunoglobulin domains and is expressed on both large and small vessels only after the endothelial cells are stimulated by cytokines. The sustained expression of VCAM-1 lasts over 24 hours. Primarily, VCAM-1 is an endothelial ligand for VLA-4 (Very Late Antigen-1 or α4β1) of the β1 subfamily of integrins and for integrin α4β7. VCAM-1 promotes the adhesion of lymphocytes, monocytes, eosinophils, and basophils. Interestingly, certain melanoma cells can use VCAM-1 to adhere to the endothelium, and VCAM-1 may participate in monocyte recruitment to atherosclerotic sites. As a result, VCAM-1 is a potential target drug target.  

View various information about this molecule at the National Center for Biotechnology Information.

 

Search similar protein and nucleotide sequences between various species using BLAST (Basic Local Alignment Search Tool)
  • Copy the desired sequence from the GenBank Database and paste it into the text box on the BLAST page.
  • Search results will provide a list of homologous molecules and show a statistical relationship between high-scoring segment pairs.
  • For more information on the results, consult the BLAST Help Manual.

 

Read the following categorized abstracts or link to Medline to conduct your own query.

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