Cadherins are a family of adhesion molecules (reviewed in Takeichi, 1990) that bind homophilically and heterophilically in a cation dependent and protease sensitive manner. Endothelial cells express at least three cadherins: N-, P-, and VE-cadherin (Vascular Endothelial Cadherin). N-cadherin is diffusely spread across the cell (Salomon et al 1992), P-cadherin is present in trace amounts (Liaw et al 1990), and VE-cadherin is specifically localized to the inter-endothelial cell junction (Lampugnani et al 1992). VE-cadherin seems important in maintaining endothelial permeability as monolayers of transfected cells show calcium-dependent reductions in permeability (Lampugnani et al 1992). Inhibition of VE-cadherin by antibodies increases both permeability and neutrophil transmigration in vivo (Gotsch et al 1997). This is in keeping with the idea that regulation of the inter-endothelial junction is an important component in the control of transmigration. A new cadherin VE-cadherin 2 has recently been described; it appears to be able to modulate homotypic adhesion, but unlike VE-cadherin does not seem to play a role in endothelial permeability (Telo et al 1998).

View various information about this molecule at the National Center for Biotechnology Information.


Search similar protein and nucleotide sequences between various species using BLAST (Basic Local Alignment Search Tool)
  • Copy the desired sequence from the GenBank Database and paste it into the text box on the BLAST page.
  • Search results will provide a list of homologous molecules and show a statistical relationship between high-scoring segment pairs.
  • For more information on the results, consult the BLAST Help Manual.


Read the following categorized abstracts or link to Medline to conduct your own query.

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