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P-selectin on endothelial cells, is the primary adhesion molecule for capture and the initiation of rolling. The main leukocyte ligand for P-selectin is PSGL-1. In addition, many in vivo studies suggest that L-selectin exhibits an important role in capture as well. Its ligand on endothelial cells is unknown. Antibodies blocking L-selectin function inhibit rolling in many models in which rolling is P-selectin dependent. Click on the picture above for a closer view. Comment on this page's content or view comments made by others!
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