LFA-1

CD11a/CD18 (LFA-1) (Lymphocyte Function-Associated Antigen-1) is critical in neutrophil transmigration, and important in transmigration of other leukocyte subtypes. CD11b (Mac-1) antibodies alone are not as potent an inhibitor of neutrophil transmigration in vitro, but it add significantly to the effect of CD11a antibodies in vitro. In vivo, both CD11a and CD11b monoclonal antibodies can reduce inflammation, suggesting both redundancy and a dependence on the inflammatory stimulus and organ involved. Antibodies to CD11b are not particularly effective in inhibiting transmigration in vitro, nor do CD11b knockout mice show defective transmigration (Lu et al 1997). CD11b monoclonal antibodies can inhibit inflammation in vivo, but in contrast to CD11a antibodies, CD11b antibodies reduce IgG immune-complex glomerulonephritis, but not IgG immune-complex lung injury (Albelda et al 1994).

View various information about this molecule at the National Center for Biotechnology Information.

 

Search similar protein and nucleotide sequences between various species using BLAST (Basic Local Alignment Search Tool)
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Read the following categorized abstracts or link to Medline to conduct your own query.

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