ICAM-1

ICAM-1 (InterCellular Adhesion Molecule-1, CD54) is a member of the immunoglobulin superfamily of adhesion molecules, and contains 5 Ig like domains. It is one of the principal ligands for the leukocyte b2-integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) (Diamond et al 1991), although in the context of transmigration it seems that CD11a predominantly binds to ICAM-1, whereas CD11b is more promiscuous (Shang et al 1998a). In vivo, ICAM-1 knock-out mice show significantly impaired neutrophil migration into an inflamed peritoneum (Bullard et al 1995; Sligh et al 1993), and ICAM-1 antibodies reduce acute and chronic inflammation in a number of animal models (Carlos et al 1994). ICAM-1 antibodies reduce cytokine-activated transmigration of neutrophils in vitro, by over 85% (Smith et al 1988; Luscinskas et al 1991). ICAM-1 is also important in chemotactic transmigration. Antibodies inhibit neutrophil chemotactic transmigration by ~55%(Furie et al 1991).

View various information about this molecule at the National Center for Biotechnology Information.

 

Search similar protein and nucleotide sequences between various species using BLAST (Basic Local Alignment Search Tool)
  • Copy the desired sequence from the GenBank Database and paste it into the text box on the BLAST page.
  • Search results will provide a list of homologous molecules and show a statistical relationship between high-scoring segment pairs.
  • For more information on the results, consult the BLAST Help Manual.

 

Read the following categorized abstracts or link to Medline to conduct your own query.

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